Metal‐catalysed exchange has been used extensively in the laboratories of AstraZeneca plc at R&D Charnwood to label a variety of molecules of pharmaceutical interest with the isotopes of deuterium and tritium. Despite early prejudices against the use of tritiated compounds, particularly in ADME studies, the development of directed isotopic exchange techniques has enabled timely and economic support for many pharmaceutical projects.
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Allen et al. (2010) studied this question.
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