Why the study?
Does transplanting normal limb-bud mesenchyme improve muscle structure and function in dystrophic mice?
Population
20-day-old normal or dystrophic C56BL/6J-dy2J mice (8 normal and 15 dystrophic test solei)
Comparison
Transplantation of mesenchymal cells dissected… vs Unoperated left solei and sham control solei…
Design
Preclinical
Follow-up
6 to 7 months
Authors
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Hypothesis-generating for mesenchymal transplantation in muscular dystrophy; further preclinical studies needed before clinical consideration.
Does transplanting normal limb-bud mesenchyme improve muscle structure and function in dystrophic mice?
Transplantation of normal limb-bud mesenchyme improves the structure and function of dystrophic muscles in a mouse model.
Peter K. Law (1982) studied this question.
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