Key result
Serum urotensin II levels were significantly higher in patients with PCOS and demonstrated a moderately strong positive correlation with insulin resistance (r = 0.44, p < 0.001).
Why the study?
Are Urotensin II levels elevated in patients with PCOS and associated with insulin resistance and hs-CRP?
Case-Control (n=89)
Are Urotensin II levels elevated in patients with PCOS and associated with insulin resistance and hs-CRP?
Urotensin II levels are elevated in PCOS and correlate with insulin resistance and inflammation, suggesting a potential role in the increased cardiovascular risk observed in these patients.
Answers are grounded in this paper and cite their sources.
Urotensin II elevation in PCOS was associated with insulin resistance; hypothesis-generating for cardiometabolic risk and requires prospective validation before clinical consideration.
UrotensinII (UII), one of the most potent vasoconstrictor proteins, may be associated with insulin resistance. The objective of our research was to determine the level of UII in sera of patients with PCOS and to investigate the relationship between UII and insulin resistance in patients with PCOS. Fourty seven PCOS patients and 42 healthy women were included in the study. Serum fasting glucose, insulin, UII, free testosterone and hs-CRP levels of the patients were examined. The HOMA-IR formula was used to calculate insulin resistance. Insulin sensitivity was calculated by using the QUICKI-IS formula. The two groups did not show any a significant difference in terms of age and BMI (p > 0.05). Serum UII, hs-CRP, insulin levels and the HOMA-IR were significantly higher in the patients with PCOS (p < 0.05). In the analysis of the correlation, UII and HOMA-IR showed statistically significant, moderately strong and positive correlation(r = 044, p < 0.001). UII and QUICKI-IS showed statistically significant, moderately strong and negative correlation(r = -0.44, p < 0.001). Also, a significant and positive correlation was found between with UII and hs-CRP(r = 0.51, p < 0.001). Our study data suggested that UII may have a role in the pathophysiology of insulin resistance and increased cardiovascular risk, which are commonly found in patients with PCOS.
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Yılmaz et al. (2013) conducted a case-control in Polycystic Ovary Syndrome (PCOS) (n=89). Polycystic Ovary Syndrome (PCOS) vs. Healthy women was evaluated on Correlation between Urotensin II (UII) and HOMA-IR (r = 0.44, p=<0.001). Serum urotensin II levels were significantly higher in patients with PCOS and demonstrated a moderately strong positive correlation with insulin resistance (r = 0.44, p < 0.001).
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