Key result
Insulin resistance affects 90% of women with PCOS and strongly correlates with fasting insulin.
Why the study?
The study aimed to evaluate the relationship between insulin resistance, biochemical parameters, and cardiometabolic risk factors in women with PCOS at tertiary care hospitals in Sindh, Pakistan.
Cross-Sectional (n=120)
Yes
Effect estimate: r = 0.892
p-value: p=< 0.001
Insulin resistance is highly prevalent (90%) in women with PCOS and strongly correlates with hyperinsulinemia and glucose dysregulation, highlighting the need for routine metabolic screening.
Fasting insulin may aid IR identification in PCOS; cross-sectional data leave causal and outcome implications open.
Objective: This study aimed to evaluate the relationship between IR, biochemical parameters, and cardiometabolic risk factors in women with PCOS at tertiary care hospitals in Sindh, Pakistan. Material and Methods: A cross-sectional study was conducted from 01 March to 31 December 2024 at Liaquat University of Medical and Health Sciences, Jamshoro. A total of 120 women aged 18–45 years with PCOS, diagnosed using the Rotterdam criteria, were included. Biochemical markers, including fasting glucose, fasting insulin, HOMA-IR, lipid profiles, and inflammatory markers (hs-CRP and IL-6), were analyzed. Pearson’s correlation was applied to determine relationships between variables. Results: The mean HOMA-IR was 6.28 (SD 2.13), with 90% of participants showing insulin resistance (HOMA-IR > 2.5). HOMA-IR demonstrated a strong positive correlation with fasting insulin (r = 0.892, p < 0.001) and a moderate positive correlation with fasting glucose (r = 0.479, p < 0.001). No significant correlations were observed between HOMA-IR and lipid profiles. Weak correlations with hs-CRP (r = 0.166, p = 0.070) and IL-6 (r = 0.054, p = 0.563) were noted. Conclusion: Insulin resistance is highly prevalent in women with PCOS and is strongly associated with hyperinsulinemia and glucose dysregulation. Routine metabolic screening and individualized interventions are critical to reduce long-term cardiometabolic risks in this population.
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Raza et al. (2025) conducted a cross-sectional in Polycystic Ovary syndrome (PCOS) (n=120). Insulin resistance (HOMA-IR) was evaluated on Correlation between HOMA-IR and fasting insulin (r = 0.892, p=< 0.001). In women with PCOS, 90% exhibited insulin resistance, which strongly correlated with fasting insulin (r = 0.892, p < 0.001) and moderately with fasting glucose (r = 0.479, p < 0.001).
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