Study of Insulin Resistance in Women with Polycystic Ovarian Syndrome Using Homeostatic Model Assessment in A Tertiary Care Hospital of Bihar

Introduction: Polycystic ovarian syndrome or PCOS, an endocrine condition, affects women of reproductive age group and characterized by features like irregular menstruation, hyperandrogenism and infertility.In India, the prevalence of PCOS is 6% more than the prevalence noted as compared to the global prevalence.Women with PCOS had higher risk of developing type 2 diabetes mellitus at an early age due to insulin resistance. Objective:The current study was done to estimate and compare level of insulin sensitivity among women of PCOS and control population. Methodology:The study was done by department of Biochemistry, DMCH, Laheriasarai.The study population comprised of 60 women aged 15-50 years of age of diagnosed case of PCOS in study group.In control group 60 women of same age group from attendants of patients, medical college staff were taken and women residing in Darbhanga.Results: Overall, the mean age of the study participants 27.8 ± 10.3 years.It was observed that as the age advances, value of HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) level increases.Values of HOMA-IR with relation to age was compared to check for any statistical association, but no statistically significant association was noted both in the study and the control population. Conclusion:Insulin resistance is common abnormality in PCOS, but it is not the universal feature.HOMA IR allow identification of insulin resistance.The test is easy to perform and cost effective, hence allowing it to be a promising screening tool.