Key result
Women with polycystic ovarian syndrome had significantly higher insulin resistance compared to healthy controls, with a mean HOMA-IR of 3.49 versus 2.68 (p=0.02).
Why the study?
Is there an association between PCOS and insulin resistance in North Indian patients?
Case-Control (n=100)
No
Is there an association between PCOS and insulin resistance in North Indian patients?
Absolute Event Rate: 3.49% vs 2.68%
p-value: p=0.02
The study confirms a strong association between PCOS and insulin resistance in a North Indian population.
Supports PCOS-insulin resistance association in North Indian women; hypothesis-generating for metabolic screening trials.
Background: Polycystic ovarian syndrome (PCOS) is most common form of chronic anovulation associated with androgen excess. Insulin resistance (IR) is characterized by impaired glucose response to specific amount of insulin. The objective of the study was to find an association between PCOS and IR in North Indian patients.Methods: A total of 50 PCOS cases diagnosed according to Rotterdam criteria, 2003, i.e. at least two of the following three features: oligomenorrhea or amenorrhea, clinical or biochemical hyperandrogenism and polycystic ovaries on ultrasound. Serum glucose levels were measured spectrophotometrically by glucose oxidase-peroxidase method. Insulin levels in serum were estimated by using ELISA based kit procured form Diasorin Ltd, Germany. Homeostatic Model Assessment- Insulin Resistance (HOMA-IR) and Body Mass Index (BMI) were calculated by their formulas. Results: PCOS patients had significantly higher values of BMI, fasting serum glucose, fasting serum insulin and HOMA-IR. Fasting serum glucose was however in the normal range in both cases and control.Conclusion: Our study suggested a strong association of PCOS with insulin resistance in this part of the country.
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Agarwal et al. (2015) conducted a case-control in Polycystic ovarian syndrome (PCOS) (n=100). Polycystic ovarian syndrome vs. Healthy age-matched women was evaluated on HOMA-IR (p=0.02). Women with polycystic ovarian syndrome had significantly higher insulin resistance compared to healthy controls, with a mean HOMA-IR of 3.49 versus 2.68 (p=0.02).
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