Key result
Insulin resistance in PCOS is associated with ~7 mg/dL lower HDL, independent of obesity.
Why the study?
Dyslipidemia, diabetes, and obesity are cardiovascular risk factors clustering in women with PCOS that cannot be explained by obesity alone, necessitating study of insulin resistance effects.
Cross-Sectional (n=50)
No
Absolute Event Rate: 35.71% vs 42.73%
p-value: p=0.001
Insulin resistance in women with PCOS is associated with an atherogenic lipid profile (high triglycerides, low HDL) independent of obesity, highlighting the need for cardiovascular risk assessment.
May support lipid assessment in IR-positive PCOS; leaves open whether IR-targeted therapy improves lipids or outcomes.
BACKGROUND: Polycystic ovary syndrome is a condition associated with chronic anovulation, insulin resistance and androgen excess.Dyslipidemia, diabetes, obesity are all potent cardiovascular risk factors that tend to cluster in women with PCOD.These cannot be explained by obesity alone.Thus the need arises to study the effect of insulin resistance on these factors.This will help in assessing the long term cardiovascular morbidity in PCOD patients and take necessary preventive steps. OBJECTIVES: To analyze the infuence of obesity on lipid profile of PCOS women. To analyze the influence of insulin resistance on lipid profile in PCOS women. MATERIALS AND METHODS:In this prospective study done from December 2013 to September 2014, 50 women with PCOS had their body mass index and waist to hip ratio calculated.GTT, fasting and post prandial insulin, lipid profile was also done for each case.Insulin resistance was defined by fasting glucose to insulin ratio of less than or equal to 4.5.The association of obesity markers and insulin resistance with lipid markers was then studied.Statistical analysis using Student t test and ANOVA was done as indicated.Significance is assessed at 5% level of significance.RESULTS: Insulin resistance was seen in 56 percent of the cases.There was no correlation between markers of obesity (BMI and Waist to Hip ratio) and the various lipid parameters.But in PCOS women with insulin resistance the lipid profile was significantly different (high triglycerides and lower high density lipoprotein) compared to the insulin sensitive women.The difference between the two groups for triglycerides and HDL was statistically significant but that for LDL and total cholesterol was not statistically significant.CONCLUSION: Insulin resistance is associated with dyslipidemia in women with PCOS, independent of obesity.
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Gowda et al. (2015) conducted a cross-sectional in Polycystic ovary syndrome (PCOS) (n=50). Insulin resistance vs. Insulin sensitive was evaluated on High-density lipoprotein (HDL) levels (p=0.001). Insulin resistance in women with PCOS was significantly associated with dyslipidemia, specifically lower HDL (35.71 vs 42.73 mg/dL) and higher triglycerides, independent of obesity.
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