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Myeloma IgG proteins become equally anticomplementary when aggregated with protein A from Staphylococcus aureus and thus contain equally efficient C-fixing sites. Furthermore, Fc fragments aggregated with protein A inactivate complement. Sheep erythrocytes stabilized with glutaric dialdehyde and coated with protein A were agglutinated by normal human IgG, by myeloma IgG, by fragment Fc from IgG, but not by fragment Fab. Thus protein A is a sensitizing substance for aldehyde-treated cells.
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Stålenheim et al. (1970) studied this question.
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