Key result
Minoxidil use was associated with a large pericardial effusion and impending tamponade that resolved and did not recur following discontinuation of the medication.
Minoxidil can cause large pericardial effusions leading to impending tamponade, which resolves upon discontinuation of the drug.
Minoxidil may cause reversible pericardial effusion; this single case leaves open systematic confirmation of causality.
A patient with a large pericardial effusion and impending tamponade exhibited clinical improvement with urgent pericardiocentesis. Further workup ruled minoxidil to be the likely cause of the effusion. After discontinuation of minoxidil, the effusion did not recur.
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Lew et al. (2023) studied this question. Minoxidil use was associated with a large pericardial effusion and impending tamponade that resolved and did not recur following discontinuation of the medication.
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