Key result
A 56-year-old man with end-stage renal disease on hemodialysis developed life-threatening cardiac tamponade due to minoxidil-induced pleuro-pericardial effusion, which resolved following urgent pericardiocentesis and drug discontinuation.
Case Report (n=1)
Minoxidil is a rare cause of pleuro-pericardial effusion with tamponade that requires prompt pericardiocentesis and drug discontinuation.
Prompt pericardiocentesis and minoxidil withdrawal may be lifesaving in ESRD tamponade; supports rare association but leaves causal confirmation open.
Minoxidil-induced pleuro-pericardial effusion is a diagnosis of exclusion after evaluation for other known causes of pericardial effusion. When complicated by cardiac tamponade, prompt pericardiocentesis and discontinuation of minoxidil can be lifesaving. We report a rare case of minoxidil-induced pleuro-pericardial effusion with tamponade in a patient with end-stage renal disease (ESRD) on hemodialysis who improved with pericardiocentesis and drug withdrawal.
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Akinleye et al. (2023) conducted a case report in Minoxidil-induced pleuro-pericardial effusion with tamponade (n=1). Minoxidil was evaluated. A 56-year-old man with end-stage renal disease on hemodialysis developed life-threatening cardiac tamponade due to minoxidil-induced pleuro-pericardial effusion, which resolved following urgent pericardiocentesis and drug discontinuation.
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