Studies on an East African strain of Plasmodium falciparum*1

An East African strain of P. falciparum was obtained from a child in Kampala, Uganda. It proved to be very responsive to all antimalarials tested. Chloroquine 0·45 g. base and quinine 2·5 g. base given over 5 days, each produced radical cure. A review of responsiveness of strains of P. falciparum used for infection of volunteers is presented. The data on the response of P. falciparum strains from different world areas indicate that sensitivity to chloroquine and quinine are closely related.