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September 1, 1964Diabetes

Blood Ketone Response to Norepinephrine-induced Free Fatty Acid Elevation in Diabetes

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Why the study?

How does norepinephrine-induced free fatty acid elevation affect blood ketone responses in diabetic versus nondiabetic subjects?

Population

Japanese nondiabetic and diabetic subjects

Comparison

Ninety-minute norepinephrine infusions vs Nondiabetic subjects, as well as internal…

Design

Other

Follow-up

90 minutes

Authors

WBWilliam G. BlackardYOYoshiaki Omori

Discussion

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Overview

May warrant ketone monitoring with catecholamines in lean diabetics; leaves open obesity's role in blunting ketosis risk.

Structured PICO

How does norepinephrine-induced free fatty acid elevation affect blood ketone responses in diabetic versus nondiabetic subjects?

P
Population
Japanese nondiabetic and diabetic subjects (including nonobese and obese individuals, with varying degrees of fasting hyperglycemia)
I
Intervention
Ninety-minute norepinephrine infusions
C
Comparator
Nondiabetic subjects, as well as internal comparisons among diabetic subjects based on obesity and degree of fasting hyperglycemia
O
Outcome
Blood free fatty acid and ketone responsessurrogate

The hyperketonemic response to norepinephrine-induced free fatty acid elevation is exaggerated in nonobese diabetics and is inversely correlated with obesity.

Cite This Study

Blackard et al. (1964) studied this question.

synapsesocial.com/papers/6a967ccbff8a6b2115f6ab7fhttps://doi.org/10.2337/diab.13.5.518
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