Key result
Clotrimazole substantially inhibited human cardiac repolarization K+ currents in vitro, including Ito1 (IC50 29.5 µM), IKur (IC50 7.6 µM), IhERG (IC50 3.6 µM), and IKs (IC50 15.1 µM).
Why the study?
Does clotrimazole affect human cardiac repolarization potassium currents in isolated human atrial myocytes and HEK 293 cells?
Population
Isolated human atrial myocytes, cloned hERG channel current, and recombinant human cardiac KCNQ1/KCNE1…
Design
Preclinical
Authors
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May increase arrhythmia risk in patients; leaves open clinical translation from in vitro data.
Does clotrimazole affect human cardiac repolarization potassium currents in isolated human atrial myocytes and HEK 293 cells?
Clotrimazole inhibits multiple human cardiac repolarization potassium currents in vitro, suggesting a potential for electrophysiological effects, though clinical relevance remains uncertain.
Tian et al. (2005) studied this question. Clotrimazole was evaluated on Inhibition of human cardiac repolarization K+ currents (Ito1, IKur, IhERG, IKs). Clotrimazole substantially inhibited human cardiac repolarization K+ currents in vitro, including Ito1 (IC50 29.5 µM), IKur (IC50 7.6 µM), IhERG (IC50 3.6 µM), and IKs (IC50 15.1 µM).
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