What question did this study set out to answer?

To comprehensively profile cross-tissue human fibroblast diversity and define how specific myofibroblast subsets regulate immune responses across inflammatory and neoplastic diseases.

September 19, 2024Cancer CellOpen Access

Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation

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Authors

YGYang GaoNanjing Agricultural University JLJianan LiFujian Normal University WCWenfeng ChengPeking University

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Implication

Single-cell transcriptomic profiling reveals distinct immunomodulatory myofibroblast subtypes across human tissues and cancers, highlighting potential targets for precision cancer therapies.

Key Points

To comprehensively profile cross-tissue human fibroblast diversity and define how specific myofibroblast subsets regulate immune responses across inflammatory and neoplastic diseases.
Analyzed single-cell RNA sequencing data from 517 human samples across 11 tissue types covering healthy, inflammatory, and cancer states.
Characterized developmental lineages, transcriptional identities, and cellular microenvironments of tissue-resident fibroblasts and myofibroblast subpopulations.
Identified four transcriptionally distinct myofibroblast lineages, revealing that LRRC15+ and MMP1+ subtypes promote immune-suppressive and immune-excluded tumor microenvironments.
Identified PI16+ fibroblasts that display anti-tumor potential in adjacent non-cancerous tissues.
Demonstrated that fibroblast-subtype compositional profiles correlate with distinct patient subgroups and clinical outcomes.

Cite This Study

Gao et al. (2024) studied this question.

synapsesocial.com/papers/6a9681dff34ac7d5e582293f https://doi.org/10.1016/j.ccell.2024.08.020

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Implication

Single-cell transcriptomic profiling reveals distinct immunomodulatory myofibroblast subtypes across human tissues and cancers, highlighting potential targets for precision cancer therapies.

Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation

Discussion

Member takes

Implication

Key Points

Cite This Study

Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation

Discussion

Member takes

Implication

Key Points

Cite This Study

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