A.H.A. committee report. Prevention of rheumatic fever

The absorption and disposition of quinidine were measured in nine patients following single oral and intravenous dos- ing.A new specific chromatographic method was used to measure the drug in plasma and urine.After intravenous administration, the plasma half-life (t+fi) was 7.8 ± 0.7 h, the volume of distribution (Vd) was 3.0 ± 0.5 liters/kg, and the total body clearance was 4.8 ± 0.8 ml/min/kg.After oral administration, 87 ± 7% (mean ± SEM) was available to the systemic circulation.Quinidine was removed pri- marily by hepatic metabolism, with the renal clearance averaging