Key result
Quinidine therapy achieved successful conversion to sinus rhythm in 82% of patients with auricular fibrillation or flutter, corresponding to a mean blood level of 5.9 mg/liter.
Why the study?
Does quinidine therapy guided by blood concentrations improve conversion to sinus rhythm in patients with auricular fibrillation or flutter?
Observational (n=30)
Does quinidine therapy guided by blood concentrations improve conversion to sinus rhythm in patients with auricular fibrillation or flutter?
Quinidine doses of 0.4 to 0.6 Gm every two hours for five doses daily are usually adequate to achieve a mean blood level of 5.9 mg/L, which is associated with an 82% success rate in converting auricular fibrillation or flutter to sinus rhythm.
Answers are grounded in this paper and cite their sources.
May support quinidine blood-level guidance for AF conversion; leaves open randomized confirmation.
Blood quinidine determinations by the photofluorometric method were made in 30 patients with auricular fibrillation or flutter in whom conversion to sinus rhythm was attempted. Successful conversion occurred in 82 per cent of the patients, with a mean blood level of 5.9 mg./liter. Vomiting and, in one case, ventricular tachycardia were the most important toxic manifestations. Doses of 0.4 to 0.6 Gm. every two hours for five doses daily were usually adequate to obtain the average conversion blood level. The importance of the quantitative aspects of quinidine therapy and the relation of time, dose and concentration of quinidine in the blood are discussed.
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Sokolow et al. (1950) conducted an observational in Auricular fibrillation or flutter (n=30). Quinidine was evaluated on Successful conversion to sinus rhythm. Quinidine therapy achieved successful conversion to sinus rhythm in 82% of patients with auricular fibrillation or flutter, corresponding to a mean blood level of 5.9 mg/liter.
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