Why the study?
Does monitoring serum quinidine concentration improve the conversion of chronic atrial fibrillation and reduce myocardial toxicity compared to dosing alone?
Population
Patients with chronic atrial fibrillation
Comparison
Quinidine therapy monitored by serum concentration vs Quinidine therapy based on dose alone
Design
Other
Authors
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Serum quinidine monitoring may limit myocardial toxicity given marked interindividual variability; leaves open whether it improves chronic AF conversion versus dose alone.
Does monitoring serum quinidine concentration improve the conversion of chronic atrial fibrillation and reduce myocardial toxicity compared to dosing alone?
Monitoring serum quinidine concentration rather than relying on dose alone may optimize the conversion of chronic atrial fibrillation while minimizing myocardial toxicity.
Sokolow et al. (1956) studied this question.
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