Why the study?
Does high-intensity exercise stress promote atrial hypertrophy and oxidative stress in Nrf2(-/-) mice compared to wild-type mice?
Population
Age and sex-matched C57/BL6/SJ wild-type (WT) and Nrf2 knock out (Nrf2-/-) mice at >20 months of age
Comparison
High-intensity exercise stress on a treadmill… vs Sedentary group (not subjected to HIES)
Design
Preclinical, Randomly assigned for high-intensity exercise (HIES) on a treadmill
Follow-up
6 weeks
Authors
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Does not inform exercise recommendations; leaves open Nrf2 as a target in atrial remodeling.
Does high-intensity exercise stress promote atrial hypertrophy and oxidative stress in Nrf2(-/-) mice compared to wild-type mice?
Loss of Nrf2 exacerbates oxidative stress, impairs autophagy, and promotes atrial hypertrophy in response to high-intensity exercise in aging mice.
Kumar et al. (2016) studied this question.
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