Why the study?
Are inflammatory and coagulation biomarkers associated with reduced cardiac autonomic function in HIV-infected individuals?
Are inflammatory and coagulation biomarkers associated with reduced cardiac autonomic function in HIV-infected individuals?
Higher levels of inflammatory and coagulation biomarkers are cross-sectionally associated with lower cardiac autonomic function in HIV patients, but do not predict longitudinal decline.
Associates inflammation/coagulation markers with reduced CAF cross-sectionally in HIV; hypothesis-generating, does not support predictive use or practice change.
AIM: To examine the relationship between inflammatory and coagulation biomarkers and cardiac autonomic function (CAF) as measured by heart rate variability in persons with HIV. MATERIALS & METHODS: This analysis included 4073 HIV-infected persons from the Strategies for Management of Antiretroviral Therapy study. We examined the association between IL-6, high-sensitivity C-reactive protein (hsCRP) and D-dimer with heart rate variability measures (SDNN and rMSSD), both cross-sectionally and longitudinally. RESULTS: Cross-sectional analysis revealed significant inverse associations between IL-6, hsCRP and d-dimer with SDNN and rMSSD (p < 0.01 for all comparisons). However, longitudinal analysis failed to show a significant association between baseline IL-6, hsCRP and d-dimer with change in CAF over time. CONCLUSION: Cross-sectionally, higher levels of inflammatory and coagulation biomarkers were associated with lower levels of CAF in the Strategies for Management of Antiretroviral Therapy trial. Although deterioration in CAF was observed during followup, baseline levels of inflammatory and coagulation markers were not predictive of the decline in CAF over time.
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Young et al. (2014) studied this question.
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