Why the study?
Type 2M von Willebrand disease is more frequently misdiagnosed as 2A or type 1 VWD than properly identified, necessitating an algorithmic approach to ensure appropriate identification.
Does a strategic algorithmic approach using sequential laboratory testing improve the correct diagnosis of 2M von Willebrand disease?
Population
Patients with types 1, 2A, 2B, and 2M VWD
Comparison
Types 1, 2A, 2B, and 2M VWD evaluated across sequential laboratory tests
Design
Comparative laboratory assessment
Authors
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May support algorithmic lab differentiation of 2M VWD; leaves open prospective validation before changing practice.
Does a strategic algorithmic approach using sequential laboratory testing improve the correct diagnosis of 2M von Willebrand disease?
A strategic algorithmic approach using specific laboratory test patterns can improve the correct diagnosis of 2M von Willebrand disease and distinguish it from other types.
Favaloro et al. (2020) studied this question.