Association Between Angiotensin Receptor Blockers and Longitudinal Decline in Tau in Mild Cognitive Impairment
Why the study?
Does angiotensin receptor blocker (ARB) use improve cerebrospinal fluid (CSF) amyloid and tau markers in patients with mild cognitive impairment?
Population
Patients with mild cognitive impairment from the longitudinal Alzheimer's Disease Neuroimaging Initiative
Design
Cohort
Authors
Discussion
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Member takes
Implication
ARB use may slow tau accumulation in MCI; extends autopsy data but leaves open randomized trials for cognitive outcomes.
Structured PICO
Does angiotensin receptor blocker (ARB) use improve cerebrospinal fluid (CSF) amyloid and tau markers in patients with mild cognitive impairment?
P
Population
Patients with mild cognitive impairment (MCI) from the longitudinal Alzheimer's Disease Neuroimaging Initiative
I
Intervention
Angiotensin receptor blocker (ARB) use
O
Outcome
Cerebrospinal fluid (CSF) amyloid and tau markerssurrogate
Cite This Study
Hajjar et al. (2015) studied this question.