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March 1, 1978Annals of Neurology

Studies of fragmented sarcoplasmic reticulum from human skeletal muscle

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Population

Sarcoplasmic reticulum vesicles isolated from muscle biopsies of 4 normal volunteers, 1 patient with McArdle…

Comparison

Measurement of ATP-dependent calcium ion uptake… vs Normal volunteers vs patients with McArdle…

Design

Preclinical

Authors

ASA. ScarpaSDS. DiMauroEBE. Bonilla

Discussion

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Overview

Normal SR Ca++ transport does not explain symptoms in McArdle disease or normokalemic periodic paralysis; leaves open alternative mechanisms for targeted research.

Structured PICO

P
Population
Sarcoplasmic reticulum vesicles isolated from muscle biopsies of 4 normal volunteers, 1 patient with McArdle disease, and 1 patient with normokalemic periodic paralysis (n=6)
I
Intervention
Measurement of ATP-dependent calcium ion uptake using kinetic analysis
C
Comparator
Normal volunteers vs patients with McArdle disease and normokalemic periodic paralysis
O
Outcome
ATP-dependent calcium ion uptake ratesurrogate

ATP-dependent calcium transport in sarcoplasmic reticulum vesicles appears normal in patients with McArdle disease and normokalemic periodic paralysis compared to healthy volunteers.

Cite This Study

Scarpa et al. (1978) studied this question.

synapsesocial.com/papers/6a968f6561dfe9432d01fee6https://doi.org/10.1002/ana.410030303
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fast kinetics of adenosine triphosphate dependent Ca<sup>2+</sup> uptake by fragmented sarcoplasmic reticulum1972 · 112 citations
  2. 2Progressive Ophthalmoplegia, Glycogen Storage, and Abnormal Mitochondria1973 · 79 citations
  3. 3Kinetics of Calcium Transport by Fragmented Sarcoplasmic Reticulum1970 · 66 citations
  4. 4Skeletal Muscle1970 · 173 citations
  5. 5Thyrotoxic periodic paralysis1973 · 19 citations