Key result
Supine ventilation and perfusion imaging in patients with mitral valve disease revealed reversed gravitational perfusion gradients, focal defects in 50%, and left lung hypoventilation in 44%.
Why the study?
Does supine regional ventilation and perfusion imaging identify pulmonary perfusion and ventilation alterations in patients with mitral valve disease compared to normal subjects?
Observational
Does supine regional ventilation and perfusion imaging identify pulmonary perfusion and ventilation alterations in patients with mitral valve disease compared to normal subjects?
Supine ventilation and perfusion imaging reveals characteristic alterations, such as reversed gravitational perfusion gradients and focal defects, in patients with mitral valve disease.
May aid characterization of pulmonary changes in mitral valve disease; hypothesis-generating and requires prospective validation before clinical adoption.
Supine tidal volume regional ventilation and perfusion images obtained in the posterior and lateral projections demonstrated several alterations in patients with mitral valve disease. Reversal of the gravitational perfusion gradient correlated with pulmonary venous and arterial hypertension; the supine studies reliably distinguished normal subjects from mitral patients. The reversed gradient was from posterior-base to anterior-apex. Focal defects were common and contributed to the reversed gradient in 50% of patients. Perfusion defects larger than those of ventilation, simulating emboli, occurred in 32%, particularly in the middle lobe and superior segment areas. Relative hypoventilation of the left lung was seen in 44% of these patients.
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Surprenant et al. (1975) conducted an observational in Mitral Valve Disease. Mitral valve disease vs. Normal subjects was evaluated on Regional pulmonary function alterations (perfusion gradients, focal defects, hypoventilation). Supine ventilation and perfusion imaging in patients with mitral valve disease revealed reversed gravitational perfusion gradients, focal defects in 50%, and left lung hypoventilation in 44%.
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