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June 1, 1965Journal of Clinical InvestigationOpen Access

Inhalation of oxygen resulted in a small but significant shift of perfusion to the lower zones from the upper (mean reduction of QU/QL 21.8%, p < 0.001).

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Why the study?

Does 100% oxygen breathing alter the regional distribution of pulmonary blood flow and ventilation in patients with mitral stenosis?

Population

15 patients with moderately severe to very severe mitral valve disease

Comparison

100% oxygen breathing for 20 to 30 minutes vs Room air breathing

Design

Cross-sectional

Authors

ADArthur DawsonKKKenzo KanekoMMMaurice McGregor

Discussion

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Overview

Indicates hypoxic vasoconstriction plays minor role in mitral stenosis; hypothesis-generating for V/Q effects, should not yet change practice.

Structured PICO

Does 100% oxygen breathing alter the regional distribution of pulmonary blood flow and ventilation in patients with mitral stenosis?

P
Population
15 patients with moderately severe to very severe mitral valve disease (mitral stenosis as the only valvular abnormality in 8, and dominant lesion in 14)
I
Intervention
100% oxygen breathing for 20 to 30 minutes
C
Comparator
Room air breathing
O
Outcome
Regional distribution of pulmonary blood flow and ventilation (measured by Xenon-133)surrogate

In patients with mitral stenosis, oxygen breathing causes a small shift of pulmonary perfusion to the lower zones, suggesting that hypoxic vasoconstriction plays only a minor role in the altered regional blood flow distribution.

Limitations

  • Uncertainties in measurement of cardiac output during oxygen breathing (assumed oxygen consumption was the same as on air for some patients)

Cite This Study

Dawson et al. (1965) studied this question.

synapsesocial.com/papers/6a6f8b1dfebe604dd708707ehttps://doi.org/10.1172/jci105217
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