Key result
Loss of consciousness at onset was strongly associated with an increased risk of unfavorable neurological outcome at 2 months in patients with non-aneurysmal subarachnoid hemorrhage (aOR 214.67).
Why the study?
Non-aneurysmal subarachnoid hemorrhages are thought to have a benign clinical course compared to aneurysmal subarachnoid hemorrhages, but their clinical course and outcomes needed reporting in a large single-center study.
Cohort (n=214)
No
Odds Ratio: 214.67 (95% CI 17.62–2615.89)
Absolute Event Rate: 68.4% vs 1.5%
p-value: p=<0.001
While non-aneurysmal subarachnoid hemorrhage generally has a favorable prognosis, loss of consciousness at onset and Fisher grade 4 bleeding pattern are strong predictors of poor neurological outcomes.
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Supports monitoring for vasospasm and hydrocephalus in non-aneurysmal SAH; leaves open whether bleed severity drives outcomes independently of etiology.
Tarkiainen et al. (2023) conducted a cohort in Non-aneurysmal subarachnoid hemorrhage (n=214). Loss of consciousness at onset vs. No loss of consciousness was evaluated on Unfavorable neurological outcome (Glasgow Outcome Scale 1-3) at 2 months (aOR 214.67, 95% CI 17.62-2615.89, p=<0.001). Loss of consciousness at onset was strongly associated with an increased risk of unfavorable neurological outcome at 2 months in patients with non-aneurysmal subarachnoid hemorrhage (aOR 214.67).
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