Key result
Ginsenoside Rb1, Rd, and Rh2 enhanced adipose differentiation of mouse 3T3-L1 fibroblasts, suggesting a structure-activity relationship to the 20(S)-protopanaxadiol aglycone group.
Why the study?
Do ginsenosides stimulate adipose differentiation in mouse 3T3-L1 fibroblasts?
Do ginsenosides stimulate adipose differentiation in mouse 3T3-L1 fibroblasts?
Ginsenosides with a 20(S)-protopanaxadiol aglycone group (Rb1, Rd, Rh2) stimulate adipose differentiation in mouse 3T3-L1 fibroblasts, demonstrating a clear structure-activity relationship.
Hypothesis-generating for ginsenoside effects on adipogenesis; leaves open any human metabolic relevance.
Some ginsenosides, extracted and purified from the roots of Panax ginseng C. A. Meyer, stimulated adipose differentiation of mouse 3T3‐L1 fibroblasts. Ginsenoside Rb1 induced adipose differentiation of 3T3‐L1 cells in a culture medium supplemented with 20% fetal calf serum, but not in one with 10% fetal calf serum. Furthermore, ginsenoside Rb1 enhanced adipose differentiation induced by insulin or dexamethasone plus 1‐methyl‐3‐isobutylxanthine (DEX‐MIX). Other ginsenosides such as ginsenoside Rd and Rh2 also enhanced DEX‐MIX‐induced adipose differentiation, but ginsenosides Re, Rg1 and Ro had no effect. These results suggest that there is a clear structure‐activity relationship to the 20(S)‐protopanaxadiol aglycone group only in stimulation of adipose differentiation.
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Sekiya et al. (1987) studied Adipose differentiation. Ginsenosides (Rb1, Rd, Rh2) vs. Control (10% vs 20% fetal calf serum, insulin, DEX-MIX) was evaluated on Adipose differentiation. Ginsenoside Rb1, Rd, and Rh2 enhanced adipose differentiation of mouse 3T3-L1 fibroblasts, suggesting a structure-activity relationship to the 20(S)-protopanaxadiol aglycone group.
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