What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Renal transplant recipients (n=66). Intervention: Serum NT-pro-BNP level. Primary outcome: Cardio-Ankle Vascular Index (CAVI) value (β: 0.459, p=<0.001).

January 1, 2013Journal of Atherosclerosis and ThrombosisOpen Access

N-terminal Pro-B-Type Natriuretic Peptide is Associated with Arterial Stiffness Measured Using the Cardio-Ankle Vascular Index in Renal Transplant Recipients

Q: What are the key findings of this study?

Serum fasting log-NT-pro-BNP level was an independent predictor of arterial stiffness measured by the cardio-ankle vascular index in renal transplant recipients (β: 0.459, p<0.001).

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Key result

Serum fasting log-NT-pro-BNP level was an independent predictor of arterial stiffness measured by the cardio-ankle vascular index in renal transplant recipients (β: 0.459, p<0.001).

Why the study?

Is serum NT-pro-BNP level associated with arterial stiffness in renal transplant recipients?

Study Design

Type

Cross-Sectional (n=66)

Multicenter

Structured PICO

Is serum NT-pro-BNP level associated with arterial stiffness in renal transplant recipients?

Population

66 renal transplant recipients, aged 31 to 73 years, were evaluated in a cross-sectional study to determine the relationship between serum NT-pro-BNP levels and arterial stiffness.

Exposure

Serum N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) level

Outcome

Arterial stiffness measured using the cardio-ankle vascular index (CAVI)surrogate

Main Result

Effect estimate: β: 0.459

p-value: p=<0.001

Serum fasting NT-pro-BNP level is independently associated with arterial stiffness in renal transplant recipients.

Limitations

Small number of enrolled patients, weakening statistical power.
Cross-sectional design prevents establishing causal relationships.
Did not assess the use of antihypertensive drugs, which have a substantial impact on arterial stiffness.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

NT-pro-BNP associates with arterial stiffness in renal transplant recipients; hypothesis-generating and should not yet change practice.

Cite This Study

Chen et al. (2013) conducted a cross-sectional in Renal transplant recipients (n=66). Serum NT-pro-BNP level was evaluated on Cardio-Ankle Vascular Index (CAVI) value (β: 0.459, p=<0.001). Serum fasting log-NT-pro-BNP level was an independent predictor of arterial stiffness measured by the cardio-ankle vascular index in renal transplant recipients (β: 0.459, p<0.001).

synapsesocial.com/papers/6a969cd418d06551b50210fe https://doi.org/10.5551/jat.17780

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N-terminal Pro-B-Type Natriuretic Peptide is Associated with Arterial Stiffness Measured Using the Cardio-Ankle Vascular Index in Renal Transplant Recipients

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

N-terminal Pro-B-Type Natriuretic Peptide is Associated with Arterial Stiffness Measured Using the Cardio-Ankle Vascular Index in Renal Transplant Recipients

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider