Cubic liquid-crystalline nanoparticles prepared from aqueous dispersions of cubic lipid-water phases are kinetically stable in the presence of certain dispersing agents. The properties of cubic nanoparticles from monoolein-water and other lipid-water systems have been examined with a variety of experimental techniques. The cubic nanoparticles can be stabilized by polymerization of the reactive lipids in cubic lipid assemblies. Several low-energy-input methods have been developed to facilitate the production and application of cubic nanoparticles. The ability to incorporate and deliver lipophilic, amphiphilic, and water-soluble molecules in a controlled manner and the good biocompatibility of cubic nanoparticles make them excellent candidates for drug-delivery applications.
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Yang et al. (2004) studied this question.
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