The Possible Effect of Vitamin D on Uric Acid Levels in Diabetic Patients

Objective: Low serum levels of Vitamin D and hyperuricemis may be associated with various problems including diabetes mellitus and cardiovascular disease. The connection of serum uric acid levels and cardiovascular events, and also diabetes mellitus has been debated for decades. There have been evidence that both Vitamin D and uric acid levels are related. In this study we aimed to investigate the relation between serum vitamin D and uric acid levels in patients with type 2 diabetes mellitus. Material and Methods:We evaluated 100 patients who were diagnosed as type 2 diabetes mellitus at least 1 year ago. Patients were divided into two groups of fifty patients with serum 25 hydroxy vitamin D levels below and above 20 ng/ ml. After evaluating the biochemical and anthropometric parameters of the groups, we compared them. We also searched correlation of Vitamin D with uric acid levels. Results: In patients with deficient Vitamin D levels, fasting blood glucose (164.6 ± 62.3 and 141.0 ± 38.6 respectively, p<0.022), body mass index (31.3 ± 4.2 and 27.5 ± 3.6 respectively, p<0.001) and uric acid levels 6.8 ± 1.0 and 4.6 ± 0.8 respectively, p<0.001) were higher than in diabetic patients with non-deficient Vitamin D levels. We also demonstrated a negative correlation between Vitamin D and uric acid levels (r: 0.488, p<0.001). Conclusion: Potential cardiovascular risk factors such as Vitamin D and uric acid are inversely related to each other. Diabetic patients who have low Vitamin D levels, have also high levels of serum fasting blood glucose and body mass index. These findings may imply that treatment of Vitamin D deficiency in diabetic patients may help the regulation of diabetes and obesity and reduction in uric acid levels and may may lessen cardiovascular events in diabetic patients.