Key result
High concentrations of adrenaline activated endogenous lipoprotein lipase activity and decreased intracellular triacylglycerol stores in the rat heart, whereas low concentrations had the opposite effect.
Intracellular lipoprotein lipase, regulated by cyclic AMP through protein kinase, may play a role in regulating endogenous triacylglycerol in the rat heart.
Adrenaline's dose-dependent effects on rat cardiac lipase and triacylglycerol stores; hypothesis-generating for human myocardial lipid metabolism.
Adrenaline has a biphasic effect on intracellular lipoprotein lipase activity and on endogenous triacylglycerol content in heparin-perfused heart. 2. A high concentration of adrenaline (1 microM in the perfusion buffer) activated endogenous lipoprotein lipase activity and, at the same time, decreased intracellular triacylglycerol stores. 3. In contrast, a low concentration (0.005 microM-adrenaline) inhibited intracellular lipoprotein lipase activity. Under these conditions, cardiac triacylglycerol content was elevated above control values. 4. Perfusing the heart with high and low concentrations of 3-isobutyl-1-methylxanthine elicited a biphasic effect on endogenous lipoprotein lipase activity and triacylglycerol content similar to that seen with adrenaline treatment. 5. The effect of adrenaline on intracellular lipoprotein lipase activity appears to be mediated by cyclic AMP through protein kinase. 6. A possible role for intracellular lipoprotein lipase in the regulation of endogenous triacylglycerol in rat heart is proposed.
No takes yet. Share an insight, caveat, or question.
Palmer et al. (1981) studied this question. Adrenaline vs. Control was evaluated on Intracellular lipoprotein lipase activity and endogenous triacylglycerol content. High concentrations of adrenaline activated endogenous lipoprotein lipase activity and decreased intracellular triacylglycerol stores in the rat heart, whereas low concentrations had the opposite effect.
Synapse has enriched one closely related paper. Consider it for comparative context: