This preclinical study demonstrates the differential regulatory effects of C apoproteins on lipoprotein lipase activity in vitro versus in situ.
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Highlights context-specific apoprotein C effects on lipolysis in rats; leaves open translational relevance to human LPL regulation.
Rat apoprotein C-II activated the hydrolysis of triacylglycerol in apoprotein-depleted chylomicrons by lipoprotein lipase in vitro and in the perfused rat heart. Apoproteins C-I and C-III-3 inhibited the hydrolysis of the triacylglycerol moiety in intact and apoprotein C-II-re-activated chylomicrons in vitro, but had no effect on the hydrolysis in situ.
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Lukens et al. (1978) studied this question.
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