Decreasing the C-II/C-III apoprotein ratio inhibits soluble lipoprotein lipase but does not affect endothelium-bound lipoprotein lipase activity in the heart.
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Hypothesis-generating for apoprotein effects on LPL; does not support altering C-II/C-III ratio to modulate cardiac endothelium-bound enzyme.
Chylomicrons with a decreased ratio of C-II/C-III apoproteins on their surface produced by the addition of apoproteins C-III-0 or C-III-3 to intact rat lymph chylomicrons. These chylomicrons inhibited the activity of soluble lipoprotein lipase in vitro, but had no effect on the activity of the endothelium-bound enzyme in the perfused heart.
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Kotlar et al. (1979) studied this question.
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