Further Observations on the Activation and Inhibition of Lipoprotein Lipase by Apolipoproteins
Population
Rat adipose tissue lipoprotein lipase and human very low density lipoprotein apolipoproteins
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for apolipoprotein modulation of LPL in lipid metabolism; human validation required before clinical relevance.
Structured PICO
P
Population
Rat adipose tissue lipoprotein lipase and human very low density lipoprotein apolipoproteins
I
Intervention
Addition of apolipoproteins (ApoC-II, ApoC-I, C-III-1, C-III-2, A-I, A-II)
O
Outcome
Activation or inhibition of lipoprotein lipase activitysurrogate
ApoC-II specifically activates lipoprotein lipase, while other apolipoproteins inhibit it, suggesting a modulatory role in VLDL triglyceride hydrolysis.
Cite This Study
Krauss et al. (1973) studied this question.