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May 1, 1980European Journal of BiochemistryOpen Access

Lipoprotein Lipase: Some Effects of Activator Proteins

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Population

In vitro model studying lipoprotein lipase and activator proteins

Comparison

Addition of activator proteins vs Absence of activator protein or presence of…

Design

Preclinical

Authors

GBGunilla BengtssonNational Institutes of HealthTOThomas OlivecronaGeneral / Preventive / Lipids

Discussion

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Implication

Preclinical activator effects on lipoprotein lipase warrant no practice change; leaves open therapeutic translation in human dyslipidemia.

Structured PICO

P
Population
In vitro model studying lipoprotein lipase and activator proteins (apolipoprotein CII from human plasma lipoproteins, T1 and T2 proteins from egg yolk lipoproteins)
I
Intervention
Addition of activator proteins (apolipoprotein CII, T1, T2)
C
Comparator
Absence of activator protein or presence of albumin
O
Outcome
Lipoprotein lipase activity (rate of triglyceride and phospholipid hydrolysis)surrogate

Activator proteins like apolipoprotein CII enhance lipoprotein lipase activity by orienting the enzyme and lipid substrate for effective hydrolysis.

Cite This Study

Bengtsson et al. (1980) studied this question.

synapsesocial.com/papers/6a6fa20c75498292b70902bdhttps://doi.org/10.1111/j.1432-1033.1980.tb04602.x

Topics

Sermorelin
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypertriglyceridemia Associated with Deficiency of Apolipoprotein C-II1978 · 606 citations
  2. 2Presence of Apolipoprotein-CII in Commercially available Albumin Fractions1979 · 7 citations
  3. 3Protein Components of Very Low Density Lipoproteins from Hen's Egg Yolk1977 · 26 citations
  4. 4Effects of Heparin on Lipoprotein Lipase from Bovine Milk1972 · 89 citations
  5. 5The Purification of a Lipoprotein Lipase from Bovine Skim Milk1972 · 176 citations