Key result
Severe rheumatoid arthritis was associated with significantly reduced left ventricular global longitudinal strain compared to non-severe disease (17.98 vs 21.29; P<0.001), which independently predicted severity.
Why the study?
The study aimed to assess myocardial functions using GLS echocardiography and arrhythmia parameters in treatment-naive newly diagnosed RA patients without clinical evidence of CVD.
Does severe rheumatoid arthritis affect myocardial function and arrhythmia parameters in treatment-naive patients without clinical CVD?
Cross-Sectional (n=77)
Does severe rheumatoid arthritis affect myocardial function and arrhythmia parameters in treatment-naive patients without clinical CVD?
Odds Ratio: 0.7 (95% CI 0.52–0.92)
Absolute Event Rate: 17.98% vs 21.29%
p-value: p=.001
In treatment-naive RA patients without clinical CVD, severe disease is associated with subclinical left ventricular systolic dysfunction and increased arrhythmia parameters.
May prompt GLS evaluation in severe RA; hypothesis-generating for arrhythmia risk, needs prospective validation.
OBJECTIVES: The cross-sectional study aimed to assess myocardial functions using global longitudinal strain (GLS) echocardiography and arrhythmia parameters with treatment naive newly diagnosed rheumatoid arthritis (RA) and no clinical evidence of cardiovascular disease (CVD). METHODS: Seventy seven newly diagnosed treatment-naive RA patients were enrolled. Disease severity was evaluated according to rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) positivity, and Disease Activity Score 28 C-reactive protein (DAS28 CRP). Myocardial functions were assessed using conventional echocardiography and GLS technique and electrocardiogram parameters cQT and Tp-e/cQT. RESULTS: Twenty three patients had severe disease while 54 patients were non-severe. The Left Ventricle GLS (17.98 ± 1.24 vs 21.29 ± 1.03, P < .001), cQT (428.71 ± 9.05 vs 394.61 ± 17.83, P < .001), Tp-e/cQT (0.19 ± 0.02 vs 0.16 ± 0.01, P < .001) for severe RA patients was reduced compared to RA non-severe patients. Penalized maximum likelihood estimation logistic regression analysis revealed LVGLS as the only significantly independent predictor of severe RA disease (OR 0.70, CI 95% 0.52-0.92, P = .001). Receiver operating characteristic (ROC) curves of the LVGLS was revealed 19.9 as GLS discriminative value with 88.8% positive predictive value for predicting severity. Severe RA risk increases when log-odds value was over 0, corresponds to LVGLS value less than 18 by partial effect plots. CONCLUSION: RA severity was associated with lower LV systolic myocardial function and increased arrhythmia parameters. Only LVGLS was significantly independent predictor of RA disease severity.
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Çakmak et al. (2020) conducted a cross-sectional in Rheumatoid arthritis (n=77). Severe rheumatoid arthritis vs. Non-severe rheumatoid arthritis was evaluated on Left Ventricle Global Longitudinal Strain (LVGLS) (OR 0.70, 95% CI 0.52-0.92, p=.001). Severe rheumatoid arthritis was associated with significantly reduced left ventricular global longitudinal strain compared to non-severe disease (17.98 vs 21.29; P<0.001), which independently predicted severity.
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