Key result
IP3 activates BKCa channels and increases their apparent Ca2+ sensitivity through local molecular coupling with type 1 IP3 receptors in arterial smooth muscle cells.
IP3R1 activation elevates BKCa channel apparent Ca2+ sensitivity through local molecular coupling in arterial smooth muscle cells.
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May guide mechanistic studies of arterial tone; leaves open clinical relevance in human vasomotor disorders.
Zhao et al. (2010) studied this question. IP3 (inositol 1,4,5-trisphosphate) was evaluated on BKCa channel activation and apparent Ca2+ sensitivity. IP3 activates BKCa channels and increases their apparent Ca2+ sensitivity through local molecular coupling with type 1 IP3 receptors in arterial smooth muscle cells.
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