Key result
In patients with hyperkalemic periodic paralysis, attacks induced by KCl or exercise caused hyperkalemia, paralysis, and up to 20% reduction in plasma water, which were alleviated by salbutamol.
Why the study?
What are the relationships between changes in plasma water, electrolytes, insulin, and catecholamines during attacks in hyperkalemic periodic paralysis, and does salbutamol alleviate them?
Population
10 patients with hyperkalemic familial periodic paralysis and 6 control subjects
Comparison
Attacks induced by KCl-ingestion or exercise… vs Control subjects receiving KCl-ingestion
Design
Case-control
Authors
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Salbutamol alleviated induced attacks in this case-control study; leaves open its role in hyperkalemic periodic paralysis pending controlled trials.
What are the relationships between changes in plasma water, electrolytes, insulin, and catecholamines during attacks in hyperkalemic periodic paralysis, and does salbutamol alleviate them?
Paralytic attacks in hyperkalemic periodic paralysis are associated with depolarization, increased Na-influx, and plasma water reduction, and can be effectively treated or prevented with salbutamol.
Clausen et al. (1980) studied Hyperkalemic familial periodic paralysis (n=16). KCl-ingestion, exercise, and salbutamol vs. Control subjects was evaluated on Changes in dynamometer strength, haematocrit, and plasma concentrations of electrolytes and hormones. In patients with hyperkalemic periodic paralysis, attacks induced by KCl or exercise caused hyperkalemia, paralysis, and up to 20% reduction in plasma water, which were alleviated by salbutamol.
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