Principles of Exercise Therapy

Introduction: There are few studies investigating the effects of abnormal glucose tolerance on functional capacity and physical activity in cystic fibrosis (CF) but yet not found a study for anaerobic power. Therefore, we aimed to compare physical activity, functional capacity, and anaerobic power in CF patients with and without impaired glucose tolerance. Method: Twenty-seven (13 M, 14F, aged 10-18 years) CF patients with impaired (CF-IGT) and 19 CF patients (11M, 8F, aged 10-17 years) without impaired glucose tolerance (CF-NGT) participated in the study. Lung function, glycated hemoglobin (HbA1c), and oral glucose tolerance test (OGTT) findings were recorded. A six-minute walk test (6MWT) was performed, and heart rate, oxygen saturation (SpO2), blood pressure, dyspnea, general, and leg fatigue using the modified Borg Scale were measured before and after the test. Anaerobic power was assessed using a vertical jump test. Peak power and average power were calculated. Bouchard Physical Activity Record was used for the assessment of physical activity level. Result: The CF-IGT group had a lower FEV1 (p=0.030) and FEF25-75% (p=0.015). The CF-IGT had a lower 6MWT distance (p=0.003), peak anaerobic power (p=0.027), and physical activity level (p=0.014) than those of CF-NGT patients. Conclusion: Physical activity, functional capacity, anaerobic power, and lung function reduced in CF patients with impaired glucose levels. Lung function is effected from increased glucose level in airway. Reduced physical activity, functional capacity, and anaerobic power may be related to disturbed skeletal muscle glucose anabolism.