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Different terms have been used in the literature for acute liver failure (ALF), i.e., fulminant hepatitis or necrosis, fulminant and subfulminant hepatic failure, and various definitions have been proposed [1–3]. In a systematic review of 41 definitions of ALF, Wlodzimirow and co-workers identified 4 components that underlined the definition of ALF and accounted for the differences: presence and/or grading of hepatic encephalopathy (HE), the interval between onset of disease and occurrence of HE, presence of coagulopathy, and pre-existing liver disease [4].
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Saliba et al. (2013) studied this question.
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