Key result
Isoelectric focusing and immunofixation identified specific band patterns for transferrin and trace proteins in CSF, and easily discriminated oligoclonal IgG in multiple sclerosis and neurosyphilis.
Observational
Isoelectric focusing with immunofixation allows for the characterization and discrimination of specific proteins, including oligoclonal IgG, in CSF and serum.
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May aid precise CSF band characterization in MS; leaves open validation against current diagnostic standards.
Laurenzi et al. (1979) conducted an observational in Multiple sclerosis and neurosyphilis. Isoelectric focusing and immunofixation was evaluated on Mobility of 17 different proteins in CSF and serum. Isoelectric focusing and immunofixation identified specific band patterns for transferrin and trace proteins in CSF, and easily discriminated oligoclonal IgG in multiple sclerosis and neurosyphilis.
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