Biochemical study demonstrates transient early postnatal synthesis of high-molecular-weight soluble glycoproteins in developing mouse brains, suggesting stage-specific roles in neural maturation.
Abstract —Incorporation of [14C]fucose or [14C]glucosamine into the glycoproteins of developing mouse brain was studied using polyacrylamide gel electrophoresis. Between 1 and 10 days after birth two fractions of soluble glycoproteins were extensively labelled, but by 15 days after birth incorporation into these fractions was no longer prominent. These glycoproteins have apparent molecular weights in the range of 150,000‐250,000, as estimated by the electrophoretic procedure. The more rapidly migrating fraction has a half‐life of about 1 week whereas the other is far more stable.
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Dutton et al. (1970) studied this question.
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