Key result
Snell dwarf mice show reduced cerebral GM3 and GM4 ganglioside turnover, retarding A pathway metabolism.
Should not change clinical practice; leaves open ganglioside roles in human pituitary dwarfism.
The ganglioside metabolism of the Snell dwarf cerebrum was examined on postnatal days 15 and 20, by monitoring the rate of incorporation of radioactivity into each ganglioside species from tritiated N-acetyl-D-mannosamine. It was found that the turnover rate of the GM3 ganglioside was reduced throughout the entire period of development, resulting in retardation of A pathway metabolism which becomes abundant during late cerebral development. In addition, the turnover rate of the GM4 species, which is considered related to myelin formation, was also found to be reduced throughout the entire period of cerebral development.
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Sugisaki et al. (1987) studied Snell dwarfism. Snell dwarfism was evaluated on Rate of incorporation of radioactivity into each ganglioside species from tritiated N-acetyl-D-mannosamine. Snell dwarf mice exhibited a reduced turnover rate of GM3 and GM4 gangliosides throughout cerebral development, resulting in retardation of A pathway metabolism.
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