Key result
Preclinical and clinical experimental models demonstrate that electrical neuromodulation for ischemic disease modulates specific central nervous system pathways involved in cardiac pain and cardiovascular regulation.
This review summarizes experimental models used to investigate the mechanisms of electrical neuromodulation in angina and myocardial ischemia.
Experimental models elucidate neuromodulation mechanisms in ischemia; leaves open clinical translation pending prospective trials.
The study of mechanisms of action underlying the use of electrical neuromodulation for angina and myocardial ischemia may illuminate heart-brain interactions that influence these conditions. To investigate these mechanisms of action, we initiated a neurocardiology program in the 1990s. This review discusses the experimental models we have studied to unravel the heart-brain interactions involved in the use of electrical neuromodulation for ischemic disease.
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DeJongste et al. (2009) conducted a review in Angina and myocardial ischemia. Electrical neuromodulation was evaluated. Preclinical and clinical experimental models demonstrate that electrical neuromodulation for ischemic disease modulates specific central nervous system pathways involved in cardiac pain and cardiovascular regulation.
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