What question did this study set out to answer?

To assess the diagnostic utility and accuracy of mean corpuscular volume (MCV) as a primary prenatal screening method for β-thalassaemia carriers.

January 1, 1985Prenatal Diagnosis

Evaluation of a prenatal screening procedure for β‐thalassaemia carriers in a chinese populationbased on the mean corpuscular volume (MCV)

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Authors

AGAnupam GhoshIndian Institute of Technology Kharagpur JWJ. S. K. WooUniversities UK CWC. W. WanOrigin Quantum Computing Technology Company (China)

Discussion

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Implication

Observational screening evaluation reveals mean corpuscular volume below 75 fl detects all beta-thalassaemia carriers in pregnant women, indicating an efficient two-step testing protocol.

Key Points

To assess the diagnostic utility and accuracy of mean corpuscular volume (MCV) as a primary prenatal screening method for β-thalassaemia carriers.
Measured haemoglobin, MCV, plasma ferritin, and HbA2 levels in 25 known β-thalassaemia carriers and an initial cohort of 299 consecutive pregnant women at less than 24 weeks of gestation.
Assessed and validated the performance of the derived MCV cut-off threshold in a subsequent screening population of 1,166 pregnant patients.
In the initial cohort, 18 of 299 women (6%) were diagnosed as carriers (HbA2 > 4.5%), with 100% presenting an MCV < 75 fl; adopting this threshold required reflex HbA2 testing in 11% of the screened population.
Lowering the MCV cut-off to 70 fl reduced reflex testing requirements to 8% (a 27% reduction) but decreased the carrier detection rate to 83%, while one third of carriers maintained normal haemoglobin levels (> 11 g/dl).
Screening of the validation cohort identified 61 carriers (6%) among 1,166 patients, all of whom presented an MCV < 75 fl, confirming 100% sensitivity for the two-step protocol.

Cite This Study

Ghosh et al. (1985) studied this question.

synapsesocial.com/papers/6a96ac2e2d8f86faeeb2f2ab https://doi.org/10.1002/pd.1970050111

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January 1, 1985Prenatal Diagnosis

Evaluation of a prenatal screening procedure for β‐thalassaemia carriers in a chinese populationbased on the mean corpuscular volume (MCV)

View Full Paper

Ask AI

Bookmark

Authors

AGAnupam GhoshIndian Institute of Technology Kharagpur JWJ. S. K. WooUniversities UK CWC. W. WanOrigin Quantum Computing Technology Company (China)

Discussion

Member takes

Implication

Observational screening evaluation reveals mean corpuscular volume below 75 fl detects all beta-thalassaemia carriers in pregnant women, indicating an efficient two-step testing protocol.

Key Points

To assess the diagnostic utility and accuracy of mean corpuscular volume (MCV) as a primary prenatal screening method for β-thalassaemia carriers.
Measured haemoglobin, MCV, plasma ferritin, and HbA2 levels in 25 known β-thalassaemia carriers and an initial cohort of 299 consecutive pregnant women at less than 24 weeks of gestation.
Assessed and validated the performance of the derived MCV cut-off threshold in a subsequent screening population of 1,166 pregnant patients.
In the initial cohort, 18 of 299 women (6%) were diagnosed as carriers (HbA2 > 4.5%), with 100% presenting an MCV < 75 fl; adopting this threshold required reflex HbA2 testing in 11% of the screened population.
Lowering the MCV cut-off to 70 fl reduced reflex testing requirements to 8% (a 27% reduction) but decreased the carrier detection rate to 83%, while one third of carriers maintained normal haemoglobin levels (> 11 g/dl).
Screening of the validation cohort identified 61 carriers (6%) among 1,166 patients, all of whom presented an MCV < 75 fl, confirming 100% sensitivity for the two-step protocol.

Cite This Study

Ghosh et al. (1985) studied this question.

synapsesocial.com/papers/6a96ac2e2d8f86faeeb2f2ab https://doi.org/10.1002/pd.1970050111

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