Key result
Metabolic alkalosis in patients with normokalemia and therapeutic digoxin concentrations was associated with a significantly greater prevalence of arrhythmias compared to patients without alkalosis.
Why the study?
Does metabolic alkalosis increase the prevalence of arrhythmias in normokalemic patients with therapeutic digoxin concentrations?
Population
Patients with normokalemia and "therapeutic" concentrations of digoxin
Comparison
Metabolic alkalosis vs Patients without alkalosis
Design
Cohort
Authors
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May support alkalosis assessment in normokalemic digoxin patients; leaves open whether correction reduces arrhythmias.
Observational
Does metabolic alkalosis increase the prevalence of arrhythmias in normokalemic patients with therapeutic digoxin concentrations?
Metabolic alkalosis increases the risk of digitalis-induced arrhythmias even when serum potassium and digoxin levels are within normal or therapeutic ranges, likely due to intracellular potassium depletion.
Brater et al. (1981) conducted an observational in Digitalis-induced arrhythmias. Metabolic alkalosis vs. Without alkalosis was evaluated on Prevalence of arrhythmias. Metabolic alkalosis in patients with normokalemia and therapeutic digoxin concentrations was associated with a significantly greater prevalence of arrhythmias compared to patients without alkalosis.
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