Key result
Neuroleptic malignant syndrome presents with significant heterogeneity in its onset, clinical course, and resolution, which can be further complicated by comorbid physical conditions.
Highlights the clinical heterogeneity of neuroleptic malignant syndrome, particularly when confounded by comorbid physical conditions.
May prompt vigilance for atypical NMS with comorbidities; leaves open generalizability beyond single-case observations.
Although neuroleptic malignant syndrome (NMS) manifests consistently with hyperthermia, muscle rigidity, altered mental state, and autonomic instability, heterogeneity exists in the onset, initial manifestations, course, laboratory findings, response to treatment, and pattern of resolution. Comorbid physical conditions tend to confuse the picture. We report a case of NMS with such a presentation.
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Srivastava et al. (2010) studied this question. Neuroleptic malignant syndrome presents with significant heterogeneity in its onset, clinical course, and resolution, which can be further complicated by comorbid physical conditions.
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