Key result
Comprehensive case report review characterizes potentially fatal neuroleptic malignant syndrome.
This review analyzes 115 case reports of neuroleptic malignant syndrome across 43 variables to summarize existing literature and guide future research.
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May aid recognition of variable neuroleptic malignant syndrome presentations; leaves open prospective validation of risk factors and diagnostics.
Neuroleptic malignant syndrome is a potentially fatal consequence of neuroleptic use that has recently gained wide attention. In this article the authors critically review the previous literature and analyze all case reports in the English-language literature (115 cases) for 43 variables. The results are discussed in light of prior literature, and recommendations are made for future research.
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Addonizio et al. (1987) studied this question. Neuroleptic malignant syndrome, a potentially fatal consequence of neuroleptic use, was characterized through a comprehensive review and analysis of 115 published case reports.
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