A reversed-phase high-performance liquid chromatography (HPLC) method utilizing an evaporative light scattering detector (ELSD) was developed for a new NMDA (N-methyl-D-aspartate) antagonist. This method permits quantitation of both the bulk drug substance purity and the related materials possible within the bulk drug substance. The method is compatible with LC/MS and the mass spectral data were obtained for each component in the bulk drug substance.
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Risley et al. (1995) studied this question.
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