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Sodium salts of lithocholic acid (3α‐hydroxy‐5β‐cholanoic acid), 5β‐cholanoic acid, Δ5‐cholenoic acid and 3‐keto‐5β‐cholanoic acid injected intracerebrally into guinea pigs in doses of 1 mg or higher produced periventricular demyelination. 24‐14C‐sodium lithocholate was rapidly released from the brain (only traces remained 2 hr after injection) if injected in quantities ranging from 2 μg to 5 mg. This rapid elimination is believed to account for the relatively high dose of lithocholate required for producing demyelination, and may also account for the limited demyelinating capacity of the other acids injected intracerebrally.
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Naqvi et al. (1970) studied this question.
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