Key result
In patients with end-stage renal disease on chronic hemodialysis without prior cardiovascular disease, 24-hour Holter monitoring revealed minor ectopic activities but no potentially lethal arrhythmias or significant conduction disorders.
Why the study?
ESRD is associated with CAD and serious ventricular arrhythmias, but whether ESRD and haemodialysis are associated with significant ECG changes required evaluation.
Are end stage renal disease and haemodialysis associated with the occurrence of significant electrocardiogram (ECG) changes?
Cross-Sectional (n=22)
No
Are end stage renal disease and haemodialysis associated with the occurrence of significant electrocardiogram (ECG) changes?
In a small cohort of ESRD patients on regular haemodialysis, no serious ECG changes or lethal arrhythmias were detected, though simple ectopic activity was common.
ESRD and HD may link to ECG changes in small cohorts; hypothesis-generating and requires prospective validation before clinical adoption.
Background: End stage renal disease (ESRD) is irreversible loss of renal function which is physiologically defined by a GFR of less than 15 ml / minute. ESRD is associated with a higher incidence of coronary artery disease and serious arrhythmia especially ventricular arrhythmia. The goal of study is to determine whether ESRD and haemodialysis (HD)are associated with occurrence of significant electrocardiogram (ECG) changes or not.Methods: This is a cross-sectional study design which involved 22 patients with ESRD on regular HD in Al Sadre teaching hospital / Al Najaf. Both sexes was included in this study. All patients underwent full medical history and examination which included the following aspects: Age, Sex, Occupation, BP, HR, RBS, B.urea, S.creatinine , Serum electrolyte (Na+, K+, Cl-, Ca++), Lipid profile (Cholesterol , Triglyceride, HDL, LDL), Duration of CRF, Duration of dialysis, Social history including (smoking, alcohol) and Drug used by the patient. Resting EGC and Hotler ECG.Results: Eighteen patients exhibited emergence of simple ectopic activity premature atrial complex (PAC) and premature ventricular complex (PVC) events and four patients exhibited (ST,T changes). Potentially lethal arrhythmias and other serious ECG changes are not detected in our patient’s sample.Conclusion: In this study, neither ESRD nor haemodialysis were associated with development of serious ECG changes or emergence of significant arrhythmia.
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Yousif et al. (2019) conducted a cross-sectional in End stage renal disease (ESRD) (n=22). Chronic hemodialysis in end-stage renal disease was evaluated on Occurrence of significant electrocardiogram (ECG) changes or serious arrhythmias. In patients with end-stage renal disease on chronic hemodialysis without prior cardiovascular disease, 24-hour Holter monitoring revealed minor ectopic activities but no potentially lethal arrhythmias or significant conduction disorders.
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